Research published online PUBMED

Authors :

  • L. Guber
  • C. Bergin
  • F. Majo


Repeated Intrastromal Injections of Voriconazole in Combination with Corneal Debridement for Recalcitrant Fungal Keratitis – a Case Series.


To report the use of intrastromal voriconazole injections combined with corneal debridement to treat deep recalcitrant fungal keratitis.


CHUV/UNIL, Switzerland.


Three patients (2 female and 1 male) with culture proven fungal keratitis (1 Fusarium, 1 Candida, 1 Pseudallescheria boydii) were included in this study. The patients were treated with repeated intrastromal voriconazole (100 mg/1 ml) in combination with corneal debridement.


Therapy and Outcome: The mean age of the patients was 65 years. The mean number of injections was 5. The patients were injected every 2-3 days. This technique required repeated corneal debridement to achieve complete resolution in these three cases.


Conclusions: Repeated intrastromal injection of voriconazole in combination with corneal debridement appears to be an effective and safe way to treat recalcitrant fungal keratitis, even in Fusarium keratitis.

+ Authors’ Information

1.Department of Ophthalmology, University of Lausanne, Fondation Asile des aveugles, Jules-Gonin Eye Hospital, Lausanne, Switzerland (Chair: Prof. Francine Behar-Cohen).